WASHINGTON — President Donald Trump will decide within two weeks whether to strike Iran, his spokeswoman said, as Israel hit more Iranian nuclear sites and warned its attacks may bring down the leadership in Tehran.

White House spokeswoman Karoline Leavitt said Trump’s message Thursday is that “based on the fact that there’s a substantial chance of negotiations that may or may not take place with Iran in the near future, I will make my decision whether or not to go within the next two weeks.”

Leavitt declined to elaborate on Trump’s timeline, including on how he views the chances of success in any further talks with Iran. The president’s goal — halting Iranian enrichment of uranium and preventing the country from obtaining nuclear weapons — remains intact, though he also believes in diplomacy if there’s a chance to use it, Leavitt told reporters at the White House.

Trump has for days publicly mused about joining Israel’s strikes on Iran, a move that would escalate the conflict in the oil-rich Middle East.

Prime Minister Benjamin Netanyahu said earlier Thursday that while Israel’s military objective remains the destruction of Iran’s nuclear and ballistic missile capabilities, “we may create the conditions” to help change the government.

In answer to whether that meant targeting Supreme Leader Ayatollah Ali Khamenei, Netanyahu said “no one is immune.” Defense Minister Israel Katz earlier mentioned Khamenei by name, saying he would “be held accountable” after Iran’s missiles struck an Israeli hospital with the two countries continuing to exchange fire.

Senior U.S. officials are preparing for the possibility of a strike on Iran in coming days, people familiar with the matter said, with some pointing to potential plans for a weekend strike. Top leaders at a handful of federal agencies have begun getting ready for an attack, one person said.

With no indication of a pause in hostilities, other international governments stepped up efforts to rein in the conflict. United Kingdom Prime Minister Keir Starmer called on Trump to keep the door open to resuming talks over Iran’s nuclear program, a sign of his concern about possible American military action. Anwar Gargash, diplomatic adviser to United Arab Emirates President Mohamed bin Zayed Al Nahyan, called for an end to hostilities and a return to dialogue.

The foreign ministers of Germany, France and the UK plan to meet Iranian Foreign Minister Abbas Araghchi in person for talks in Geneva on Friday. The European Union’s top diplomat, Kaja Kallas, will be present. Meanwhile, U.S. Secretary of State Marco Rubio has spoken with his Italian counterpart and is scheduled to meet UK Foreign Secretary David Lammy in Washington on Thursday.

Araghchi said Wednesday that Iran remains “committed to diplomacy” and has never sought and would never seek nuclear weapons. Khamenei said the same day he won’t surrender.

A missile from Iran on Thursday struck an Israeli hospital for the first time since the war started, a reminder of the risks to civilians in both countries. Israel’s Health Ministry said there were only a number of light injuries in the incident at Soroka Medical Center in the south of the country, as the missile landed in a department that had been evacuated hours earlier.

The impact of the morning salvo was magnified by what Israel described as Iran’s use of a missile with a warhead that broke into dozens of submunitions that scattered widely before exploding on the ground.

A Bloomberg reporter heard a blast overhead before the impacts, which appeared to correspond to the Israeli military’s analysis of the kind of missile used. The fragmented-warhead missile was unveiled by Iran in 2017, according to the Center for Strategic and International Studies in Washington.

Israel’s campaign shows no sign of letting up, with jets striking dozens of military targets in Iran overnight, including an inactive nuclear reactor in the area of Arak. The country will escalate attacks on Iranian strategic and government targets, Katz said.

Arak has long been the focus of international scrutiny due to its potential role in plutonium production, which could be used in future nuclear-weapon production if reprocessing capabilities were developed. The Arak-Khondab region area, situated in central Iran, is itself strategically significant as it is home to some of the country’s most critical atomic infrastructure.

European stocks and U.S. futures edged lower on geopolitical uncertainty and concerns about the inflationary impact of higher crude prices. Brent rose 1.6%, trading close to $78 per barrel. Cash trading in US stocks and Treasuries is closed for the Juneteenth holiday.

On Saturday, the Iranian minister is expected to attend the Organization of Islamic Cooperation meeting in Istanbul, Turkish news channel NTV reported, citing diplomatic sources it didn’t identify. A special session on the war between Israel and Iran is planned.

Iran also imposed a nationwide internet and telephone blackout on Thursday, telling civilians it’s necessary to prevent Israeli cyberattacks.

Trump told reporters at the White House Wednesday he has “ideas as to what to do” and that he prefers to make the “final decision one second before it’s due” because the situation is fluid.

A few hours earlier, Trump had said, “I may do it. I may not do it,” when asked if he was moving closer to attacking Iran.

A White House official said that all options remain on the table.

Change of Tone

The president’s openness to war is a reversal from his public remarks a week ago, when Trump was urging diplomatic talks to reach a nuclear disarmament deal with Iran.

Waiting a few days to strike gives Iranian leaders additional runway to demonstrate to Trump they are willing to give up some uranium enrichment capabilities to deter a U.S. attack.

International Atomic Energy Association inspectors “have not seen” any structured effort by Iran to produce nuclear weapons, but “no country in the world is enriching uranium at this level,” the United Nations watchdog’s director general, Rafael Mariano Grossi, told Bloomberg Television on Wednesday.

Since Israel first attacked Iran last Friday, hundreds of people have been killed. At least 224 Iranians have died, mostly civilians, according to Iran’s health ministry. Israel says 400 ballistic missiles and hundreds of drones fired by Iran killed 24 people and injured more than 800, according to the Israeli emergency services.

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